RT600-UV UV Online Automatic Detection Dissolution System is the latest product launched by Raytor Instruments based on the third generation dissolution operating system. RT600-UV dissolution system includes dissolution apparatus, automatic sampling workstation and UV-Vis spectrophotometer. RT600-UV supports automatic dissolution sampling and automatic UV online detection, which is more convenient for drug research and development and routine detection, and greatly improves work efficiency. (1) Each dissolution vessel has an independent sample colorimetric flow cell and pipe to effectively avoid cross contamination between samples of different dissolution vessels. (2) The dissolution operating system controls the automatic dissolution apparatus, automatic sampling workstation and UV-Vis spectrophotometer, and supports the preset and call of the dissolution UV online automatic detection method. The dissolution system will automatically complete the automatic dissolution sampling and automatic online UV detection according to the preset method. The test results will be fed back to the interface of the dissolution operating system in real time and automatically monitored Automatically generate protected electronic data d0cuments in real time. (3)Raytor's advanced dissolution operating system can ensure full compliance with data integrity requirements, audit tracking requirements, account management requirements and other regulatory requirements. Raytor UV online automatic detection dissolution system has excellent accuracy and stability, and can ensure the accuracy and stability of test results even in the face of harsh test conditions. Accuracy Thanks to the advanced automatic sampling technology of Raytors Instruments, the accuracy of RT600-UV dissolution system can reach a high level. Excellent accuracy can ensure that the UV online test can truly reflect the real-time dissolution of samples, and the test results are more real and reliable. Test Case: Performed manual sampling test and UV online test respectively, and the continuous detected the salicylic acid solution with the concentration of 6, 9, 12,18, 24,36 μg / ml. Taking salicylic acid concentration as X axis and sample absorbance (Abs) as Y axis, established a linear regression curve, and calculated the R square value of each curve was. The results of UV online test showed excellent linear correlation, and the R square value was 0.9995, which had no significant difference from the manual sampling control group (0.9999). Established a linear regression curve using the absorbance (Abs) of the manual sampling control group as the X-axis, and the absorbance (Abs) of the UV online test group is the Y-axis. Its R square value is 0.9996. The results show that Raytor online UV automatic detection dissolution system has excellent accuracy. Repeatability The test results need not only accuracy, but also repeatability. Raytor UV online automatic detection dissolution system has excellent repeatability to ensure that the UV online test results of continuous automatic sampling are stable and reliable. Test Case: Use RT600-UV dissolution system to continuously perform on-line sampling for 10 times for the sample solution of the same concentration (each sampling interval is 5 minutes). For example, in the sample test group with lower concentration, the relative standard deviation (RSD) of 10 test results is 1.2%, and the difference between the average absorbance of UV online test (0.2916) and that of manual sampling test (0.2904) is 0.4%. The test results fully show that Raytor UV online automatic detection dissolution system has excellent accuracy and stability at the same time. Multichannel UV Online Detection Raytor UV online automatic detection dissolution system can connect 8-channel UV online detection pipe at the same time. Among them, 6 channel pipes are used for online detection of sample dissolution rate, 1 channel pipe is used for blank calibration, and 1 channel pipe is reserved for reference test. Through the operating system, the automatic dissolution test procedure of "drug dosing → test running → sampling → UV detection" can be simply realized, and the experimental efficiency can be greatly improved. Test Case: Perform dissolution test by using the RT600-UV dissolution system with dissolution parameters as : Basket method; Speed: 100RPM; Dissolution medium: 900ml pure water; Temperature: 37.0 ℃; UV detection wavelength: 257nm. After the automatic synchronous dosing of the sample, the system will automatically sample every 5 minutes and perform UV online detection. The concentration of the sample solution is converted through the absorbance results, and the dissolution rate is further obtained. The test results of sample dissolution rate are as follows: The UV online detection results of different channels are in good agreement, and the sample dissolution can be presented accurately and in real time. Raytor UV online automatic detection dissolution system makes the drug dissolution test more accurate, convenient and efficient.
More +